Show se uskutečnila 24. dubna 2021 v VyStar Veterans Memorial Arena (Jacksonville, Florida). Na hlavní kartě se sešlo pět zápasů. 1) Anthony Smith vs. Jimmy Crute 2) Chris Weidman vs. Uriah Hall 3) Valentina Shevchenko (c) vs. Jéssica Andrade (UFC Womens Flyweight Championship) 4) Zhang Weili (c) vs. Rose Namajunas (UFC Womens Strawweight Championship) 5) Kamaru Usman (c) vs. Jorge Masvidal (UFC Welterweight Championship) (TheSpearCZ)